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medication information
Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Also, in some persons histamine can close up the bronchial tubes (air passages of the lungs) and make breathing difficult.

Some of the antihistamines are also used to prevent motion sickness, nausea, vomiting, and dizziness. In patients with Parkinson's disease, diphenhydramine may be used to decrease stiffness and tremors. Also, the syrup form of diphenhydramine is used to relieve the cough due to colds or hay fever. In addition, since antihistamines may cause drowsiness as a side effect, some of them may be used to help people go to sleep.

Hydroxyzine is used in the treatment of nervous and emotional conditions to help control anxiety. It can also be used to help control anxiety and produce sleep before surgery.

Some antihistamines are used in the treatment of chronic urticaria, which is a persistent hive-like rash.



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how to take this medication
Antihistamines are used to relieve or prevent the symptoms of your medical problem. Take them only as directed. Do not take more of them and do not take them more often than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of side effects.

Dosing˜

The dose of an antihistamine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of antihistamines. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules or tablets or teaspoonfuls of liquid that you take or the number of suppositories you use depends on the strength of the medicine. Also, the number of doses you take each day and the time between doses depends on whether you are taking a short-acting or long-acting form of antihistamine.

For use as an antihistamine:
For azatadine
For oral dosage form (tablets):
Adults: 1 to 2 milligrams (mg) every eight to twelve hours as needed.
Children younger than 12 years of age: Use and dose must be determined by your doctor.
Children 12 years of age and older: 0.5 mg to 1 mg two times a day as needed.
For brompheniramine
For regular (short-acting) oral dosage forms (capsules, tablets, or liquid):
Adults and teenagers: 4 milligrams (mg) every four to six hours as needed.
Children 2 to 6 years of age: 1 mg every four to six hours as needed.
Children 6 to 12 years of age: 2 mg every four to six hours as needed.
For injection dosage form:
Adults and teenagers: 10 milligrams (mg) injected into a muscle, under the skin, or into a vein every eight to twelve hours.
Children younger than 12 years of age: 0.125 mg per kilogram (0.06 mg per pound) of body weight injected into a muscle, under the skin, or into a vein three or four times a day as needed.
For cetirizine
For oral dosage forms (syrup and tablets):
Adults: 5 to 10 milligrams (mg) once a day.
Children younger than 2 years of age: Use and dose must be determined by your doctor.
Children 2 to 6 years of age: 2.5 mg once a day, up to a maximum of 5 mg once a day or 2.5 mg twice a day.
Children 6 years of age and older: 5 to 10 mg once a day.
For chlorpheniramine
For regular (short-acting) oral dosage forms (tablets or liquid):
Adults and teenagers: 4 milligrams (mg) every four to six hours as needed.
Children younger than 6 years of age: Use and dose must be determined by your doctor.
Children 6 to 12 years of age: 2 mg three or four times a day as needed.
For long-acting oral dosage forms (capsules or tablets):
Adults: 8 or 12 milligrams (mg) every eight to twelve hours as needed.
Children younger than 12 years of age: Use and dose must be determined by your doctor.
Children 12 years of age and older: 8 mg every twelve hours as needed.
For injection dosage form:
Adults: 5 to 40 milligrams (mg) injected into a muscle, into a vein, or under the skin.
Children: 0.0875 mg per kilogram (0.04 mg per pound) of body weight injected under the skin every six hours as needed.
For clemastine
For oral dosage forms (tablets or liquid):
Adults and teenagers: 1.34 milligrams (mg) two times a day or 2.68 mg one to three times a day as needed.
Children younger than 6 years of age: Use and dose must be determined by your doctor.
Children 6 to 12 years of age: 0.67 to 1.34 mg two times a day.
For cyproheptadine
For oral dosage forms (tablets or liquid):
Adults and children 14 years of age and older: 4 milligrams (mg) every eight hours. The doctor may increase the dose if needed.
Children 2 to 6 years of age: 2 mg every eight to twelve hours as needed.
Children 6 to 14 years of age: 4 mg every eight to twelve hours as needed.
For desloratadine
For oral dosage form (tablets):
Adults and children 12 years of age and older: 5 milligrams (mg) once a day.
Children younger than 12 years of age: Use and dose must be determined by your doctor.
For dexchlorpheniramine
For regular (short-acting) oral dosage forms (tablets or liquid):
Adults and teenagers: 2 milligrams (mg) every four to six hours as needed.
Children 2 to 5 years of age: 0.5 mg every four to six hours as needed.
Children 5 to 12 years of age: 1 mg every four to six hours as needed.
For long-acting oral dosage form (tablets):
Adults: 4 or 6 milligrams (mg) every eight to twelve hours as needed.
Children: Use and dose must be determined by your doctor.
For diphenhydramine
For oral dosage forms (capsules, tablets, or liquid):
Adults and teenagers: 25 to 50 milligrams (mg) every four to six hours as needed.
Children younger than 6 years of age: 6.25 to 12.5 mg every four to six hours.
Children 6 to 12 years of age: 12.5 to 25 mg every four to six hours.
For injection dosage form:
Adults: 10 to 50 milligrams (mg) injected into a muscle or into a vein.
Children: 1.25 mg per kg (0.6 mg per pound) of body weight injected into a muscle four times a day.
For doxylamine
For oral dosage form (tablets):
Adults and teenagers: 12.5 to 25 milligrams (mg) every four to six hours as needed.
Children younger than 6 years of age: Use and dose must be determined by your doctor.
Children 6 to 12 years of age: 6.25 to 12.5 mg every four to six hours as needed.
For fexofenadine
For oral dosage forms (capsules):
Adults and teenagers: 60 milligrams (mg) two times a day as needed or 180 mg once a day
Children 6 to 11 years of age: 30 mg twice a day as needed.
Children under 6 years of age: Use and dose must be determined by your doctor.
For loratadine
For oral dosage forms (tablets or liquid):
Adults and children 6 years of age and older: 10 milligrams (mg) once a day.
Children 2 to 5 years of age: 5 mg once a day.
For phenindamine
For oral dosage form (tablets):
Adults and teenagers: 25 milligrams (mg) every four to six hours as needed.
Children younger than 6 years of age: Use and dose must be determined by your doctor.
Children 6 to 12 years of age: 12.5 mg every four to six hours as needed.
For nausea, vomiting, and vertigo (only dimenhydrinate and diphenhydramine are used for vertigo):
For dimenhydrinate
For regular (short-acting) oral dosage forms (tablets or liquid):
Adults and teenagers: 50 to 100 milligrams (mg) every four to six hours as needed.
Children 2 to 6 years of age: 12.5 to 25 mg every six to eight hours as needed.
Children 6 to 12 years of age: 25 to 50 mg every six to eight hours as needed.
For long-acting oral dosage form (capsules):
Adults: 1 capsule (contains 25 milligrams [mg] for immediate action and 50 mg for long action) every twelve hours.
Children: Use and dose must be determined by your doctor.
For injection dosage form:
Adults: 50 milligrams (mg) injected into a muscle or into a vein every four hours as needed.
Children: 1.25 mg per kg (0.6 mg per pound) of body weight injected into a muscle or into a vein every six hours as needed.
For suppository dosage form:
Adults: 50 to 100 milligrams (mg) inserted into the rectum every six to eight hours as needed.
Children younger than 6 years of age: Use and dose must be determined by your doctor.
Children 6 to 8 years of age: 12.5 to 25 mg inserted into the rectum every eight to twelve hours as needed.
Children 8 to 12 years of age: 25 to 50 mg inserted into the rectum every eight to twelve hours as needed.
Children 12 years of age and older: 50 mg inserted into the rectum every eight to twelve hours as needed.
For diphenhydramine
For oral dosage forms (capsules, tablets, or liquid):
Adults: 25 to 50 milligrams (mg) every four to six hours as needed.
Children: 1 to 1.5 mg per kg (0.45 to 0.7 mg per pound) of body weight every four to six hours as needed.
For injection dosage form:
Adults: 10 milligrams (mg) injected into a muscle or into a vein. Dose may be increased to 25 to 50 mg every two to three hours.
Children: 1 to 1.5 mg per kg (0.45 to 0.68 mg per pound) of body weight injected into a muscle every six hours.
For hydroxyzine
For oral dosage forms (capsules, tablets, or liquid):
Adults: 25 to 100 milligrams (mg) three or four times a day as needed.
Children younger than 6 years of age: 12.5 mg every six hours as needed.
Children 6 years of age and older: 12.5 to 25 mg every six hours as needed.
For injection dosage form:
Adults: 25 to 100 milligrams (mg) injected into a muscle.
Children: 1 mg per kg (0.45 mg per pound) of body weight injected into a muscle.
For Parkinson's disease:
For diphenhydramine
For oral dosage forms (capsules, tablets, or liquid):
Adults: 25 milligrams (mg) three times a day when starting treatment. Your doctor may increase the dose gradually later if needed.
For injection dosage form:
Adults: 10 to 50 milligrams (mg) injected into a muscle or into a vein.
Children: 1.25 mg per kg (0.6 mg per pound) of body weight four times a day injected into a muscle.
For use as a sedative (to help sleep):
For diphenhydramine
For oral dosage forms (capsules, tablets, or liquid):
Adults: 50 milligrams (mg) twenty to thirty minutes before bedtime if needed.
For doxylamine
For oral dosage form (tablets):
Adults: 25 milligrams (mg) thirty minutes before bedtime if needed.
Children: Use and dose must be determined by your doctor.
For hydroxyzine
For oral dosage forms (capsules, tablets, or liquid):
Adults: 50 to 100 milligrams (mg).
Children: 0.6 mg per kg (0.3 mg per pound) of body weight.
For injection dosage form:
Adults: 50 milligrams (mg) injected into a muscle.
For anxiety:
For hydroxyzine
For oral dosage forms (capsules, tablets, or liquid):
Adults: 50 to 100 milligrams (mg).
Children: 0.6 mg per kilogram (0.3 mg per pound) of body weight.
For injection dosage form:
Adults: 50 to 100 milligrams (mg) injected into a muscle every four to six hours as needed.
Children: 1 mg per kilogram (0.45 mg per pound) of body weight injected into a muscle.


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side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if the following side effect occurs:

Less common or rare
Less frequent or rare with azatadine, cetirizine, clemastine, cyproheptadine, desloratadine, dexchlorpheniramine, diphenhydramine, or loratadine

Fast or irregular heartbeat; fever; abdominal or stomach pain; burning; chills; clay-colored stools or dark urine; cough; diarrhea; difficulty swallowing; dizziness; fast heartbeat; fever; headache; hives; itching; prickly sensations; puffiness or swelling of the eyelids or around the eyes, face, lips or tongue ; redness of skin; seizures ; shortness of breath; skin rash; swelling; tightness in chest; tingling; unusual tiredness or weakness; wheezing


Also, check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare
Sore throat; unusual bleeding or bruising ; unusual tiredness or weakness


Symptoms of overdose
Clumsiness or unsteadiness; convulsions (seizures); drowsiness (severe); dryness of mouth, nose, or throat (severe); feeling faint; flushing or redness of face; hallucinations (seeing, hearing, or feeling things that are not there); shortness of breath or troubled breathing ; trouble in sleeping


Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your health care professional if any of the following side effects continue or are bothersome:

More common
Drowsiness; dry mouth, nose, or throat ; gastrointestinal upset, stomach pain, or nausea ; headache; increased appetite and weight gain; thickening of mucus


Less common or rare
Acid or sour stomach; belching; blurred vision or any change in vision; clumsiness or unsteadiness; body aches or pain; confusion (not with diphenhydramine); congestion; constipation; cough; diarrhea; difficult or painful urination; difficulty in moving; difficult or painful menstruation; dizziness (not with brompheniramine or hydroxyzine; drowsiness (with high doses of desloratadine and loratadine); dryness of mouth, nose, or throat; early menstruation; fast heartbeat; fatigue; fever; gastrointestinal upset, stomach pain or nausea; heartburn; hoarseness; increased appetite and weight gain; increased sensitivity of skin to sun; increased sweating; indigestion; loss of appetite; joint pain; muscle aching or cramping ; muscle pains or stiffness; nausea; nightmares (not with azatadine, chlorpheniramine, cyproheptadine, desloratadine, hydroxyzine, or loratadine); ringing or buzzing in ears; runny nose; skin rash; swollen joints; stomach discomfort, upset or pain; tender swollen glands in neck; thickening of mucus ; tremor; unusual excitement, nervousness, restlessness, or irritability; vomiting


Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your health care professional.



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precautions
Before you have any skin tests for allergies, tell the doctor in charge that you are taking this medicine. The results of the test may be affected by this medicine.

When taking antihistamines on a regular basis, make sure your doctor knows if you are taking large amounts of aspirin at the same time (as for arthritis or rheumatism). Effects of too much aspirin, such as ringing in the ears, may be covered up by the antihistamine.

Antihistamines will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

This medicine may cause some people to become drowsy or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Some antihistamines are more likely to cause drowsiness than others. Drowsiness is less likely with cetirizine, and rare with desloratadine and loratadine. Make sure you know how you react to the antihistamine you are taking before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Antihistamines may cause dryness of the mouth, nose, and throat. Some antihistamines are more likely to cause dryness of the mouth than others . For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

For patients using dimenhydrinate, diphenhydramine, or hydroxyzine:

This medicine controls nausea and vomiting. For this reason, it may cover up the signs of overdose caused by other medicines or the symptoms of appendicitis. This will make it difficult for your doctor to diagnose these conditions. Make sure your doctor knows that you are taking this medicine if you have other symptoms of appendicitis such as stomach or lower abdominal pain, cramping, or soreness. Also, if you think you may have taken an overdose of any medicine, tell your doctor that you are taking this medicine.
For patients using diphenhydramine or doxylamine as a sleeping aid:

If you are already taking a sedative or tranquilizer, do not take this medicine without consulting your doctor first.



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notes
Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Also, in some persons histamine can close up the bronchial tubes (air passages of the lungs) and make breathing difficult.

Some of the antihistamines are also used to prevent motion sickness, nausea, vomiting, and dizziness. In patients with Parkinson's disease, diphenhydramine may be used to decrease stiffness and tremors. Also, the syrup form of diphenhydramine is used to relieve the cough due to colds or hay fever. In addition, since antihistamines may cause drowsiness as a side effect, some of them may be used to help people go to sleep.

Hydroxyzine is used in the treatment of nervous and emotional conditions to help control anxiety. It can also be used to help control anxiety and produce sleep before surgery.

Some antihistamines are used in the treatment of chronic urticaria, which is a persistent hive-like rash.

Antihistamines may also be used for other conditions as determined by your doctor.

Some antihistamine preparations are available only with your doctor's prescription. Others are available without a prescription. However, your doctor may have special instructions on the proper dose of the medicine for your medical condition.

These medicines are available in the following dosage forms:

Oral
Azatadine
Tablets (U.S. and Canada)
Brompheniramine
Capsules (U.S.)
Elixir (U.S. and Canada)
Tablets (Canada)
Cetirizine
Syrup (U.S.)
Tablets (U.S. and Canada)
Chlorpheniramine
Extended-release capsules (U.S.)
Syrup (U.S. and Canada)
Tablets (U.S. and Canada)
Chewable tablets (U.S.)
Extended-release tablets (U.S. and Canada)
Clemastine
Syrup (U.S. and Canada)
Tablets (U.S. and Canada)
Cyproheptadine
Syrup (Canada)
Tablets (U.S. and Canada)
Desloratadine
Tablets (U.S. and Canada)
Dexchlorpheniramine
Syrup (U.S. and Canada)
Tablets (U.S. and Canada)
Extended-release tablets (U.S. and Canada)
Dimenhydrinate
Extended-release capsules (Canada)
Oral Solution (U.S. and Canada)
Syrup (U.S. and Canada)
Tablets (U.S. and Canada)
Chewable tablets (U.S. and Canada)
Diphenhydramine
Capsules (U.S. and Canada)
Elixir (U.S. and Canada)
Tablets (U.S.)
Doxylamine
Tablets (U.S.)
Fexofenadine
Tablets (U.S. and Canada)
Capsules (U.S. )
Hydroxyzine
Capsules (U.S. and Canada)
Oral suspension (U.S.)
Syrup (U.S. and Canada)
Tablets (U.S.)
Loratadine
Syrup (U.S. and Canada)
Tablets (U.S. and Canada)
Phenindamine
Tablets (U.S.)
Parenteral
Brompheniramine
Injection (U.S.)
Chlorpheniramine
Injection (U.S. and Canada)
Dimenhydrinate
Injection (U.S. and Canada)
Diphenhydramine
Injection (U.S. and Canada)
Hydroxyzine
Injection (U.S. and Canada)
Rectal
Dimenhydrinate
Suppositories (Canada)



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missed dosage
If you are taking this medicine regularly and you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

For patients taking this medicine by mouth:

Antihistamines can be taken with food or a glass of water or milk to lessen stomach irritation if necessary.
If you are taking the extended-release tablet form of this medicine, swallow the tablets whole. Do not break, crush, or chew before swallowing.
For patients taking dimenhydrinate or diphenhydramine for motion sickness:

Take this medicine at least 30 minutes or, even better, 1 to 2 hours before you begin to travel.
For patients using the suppository form of this medicine:

To insert suppository: First remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum. If the suppository is too soft to insert, chill the suppository in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper.
For patients using the injection form of this medicine :

If you will be giving yourself the injections, make sure you understand exactly how to give them. If you have any questions about this, check with your health care professional.


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storage
To store this medicine:

Keep out of the reach of children, since overdose may be very dangerous in children.
Store away from heat and direct light.
Do not store the capsule or tablet form of this medicine in the bathroom medicine cabinet, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
Keep the liquid form of this medicine from freezing.
Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.



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